September 24 in NYC: “Searching the Genome for Cancer’s Achilles’ Heel”

Tim WangPlease join us for a special presentation and cocktail reception on Thursday, September 24 at 6:00 pm at the home of Ruth and Jim Scheuer with Tim Wang, a scientist in David Sabatini’s lab.

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About the Speaker
Tim Wang is a graduate student in the Department of Biology at MIT conducting his thesis research in the laboratories of Whitehead member David Sabatini and former Whitehead member Eric Lander. He has pioneered the development of a novel method for conducting genetic screens in human cells which will greatly accelerate the study of gene function and our understanding of human diseases.

Recent cancer genome sequencing efforts have provided a detailed survey of the mutational events that occur during tumor development. From these studies, the list of frequently mutated ‘driver’ genes in human cancer has emerged. However, many of these genes are currently considered to be ‘undruggable’. To tackle this challenge, Wang has taken a complementary approach using his recently developed screening technology to identify highly cancer-specific vulnerabilities. Such an Achilles’ heel of cancer may be exploited for the development of targeted anti-neoplastic therapies.

In addition, he has used the screening platform as tool to study other disease processes such as HIV infection and the trafficking of CFTR, the gene linked to cystic fibrosis.

Wang received his Bachelor’s Degree in Bioengineering from UC Berkeley and began his cancer research career in the laboratory of Scott Powers at Cold Spring Harbor Laboratory. He has received numerous awards and honors including a Graduate Research Fellowship from the National Science Foundation, a National Research Service Award from the National Institutes of Health and an International Young Investigator Award from Lund University.