hidde ploegh and david sabatini

Whitehead Members Hidde Ploegh and David Sabatini Elected to National Academy of Sciences

CAMBRIDGE, Mass. (May 3, 2016) – The National Academy of Sciences announced today that Whitehead Institute’s Hidde Ploegh […]

David Page and Rudolf Jaenisch

Reimagining Genetics: 2016 Whitehead Symposium

The 2016 Whitehead Symposium Reimagining Genetics: New Views on Heart, Brain & Autoimmune Diseases Friday, May 6, […]

Kate Rubins

Today at 2 p.m. EST: Stream NASA news conference with astronaut and former Whitehead Fellow Kate Rubins

Whitehead Fellow turned astronaut Kate Rubins will appear in a NASA news conference today at 2 p.m. […]

David Sabatini

Scientists identify metabolic pathway mutations in follicular lymphoma

A team of researchers from Whitehead Institute and Queen Mary University of London (QMUL) have identified in […]

Susan Lindquist

Susan Lindquist profiled in the latest issue of The Scientist magazine

Fearless about Folding By Anna Azvolinsky | January 1, 2016 The Scientist As a junior faculty member […]

Ifat Rubin-Bejerano

Whitehead Connects presents Yaniv Bejerano and Ifat Rubin-Bejerano, ImmuneXcite

“From immune recognition of fungi to immunotherapy of cancer” February 10, 2016 5:30 presentation; 6:30 networking reception […]

Hazel Sive photo

January 27 in NYC: “Fishing for clues to unravel the complex genetics of autism and other brain disorders”

Please join us for a special presentation and cocktail reception on Wednesday, January 27 at 6:00 pm […]

This schematic shows how amino acid inputs arising from multiple sensors in distinct cellular compartments impinge on the Rag GTPases to control the activity of the growth-regulating mTORC1 pathway. The protein Sestrin2 (and likely Sestrin1) binds leucine, disrupting an interaction between Sestrin2 and GATOR2, which in turn activates mTORC1.

Scientists discover essential amino acid sensor in key growth-regulating metabolic pathway

Whitehead Institute scientists have at last answered the long-standing question of how the growth-regulating pathway known as […]